After 24 hours of completing treatment perform a 25% water change and you may now turn back ON Protein skimmer, resume use of carbon and ozone, although you may notice extra foam being produced by your Skimmer. If Cyano Bacteria is still viable, 48 hours after treatment, perform a 25% water change and repeat dosage.
Note: It is recommended that the pH in your aquarium be greater than 8.0, before you begin to add Red Cyano Rx. The best time to start treatment is in the morning, when lighting first comes on. Also, it is important to perform a 25% water change, within 12 hours, following each dose. You will need to discontinue the use of carbon, protein skimming, and ozone during the treatment period. Do not dose in the evenings when lighting is turned off.